By inhibiting the expression of ICAM-1/VCAM-1 and suppressing the phosphorylation and internalization of VE-cadherin, 4-OI effectively reduces leukocyte adhesion and vascular leakage, which are critical factors in sepsis-induced organ injury (Dejana et al. 2008; Ley et al. 2007). Here, ICAM1 is linked to Sepsis.