In addition, Further studies identified that LCN2 and SOCS3 were the downstream targets of EGR1. The above findings suggest that IL-1α, IL-1β and IL-6 secreted from M1-polarized macrophages stimulated by abnormally elevated TSH upregulate EGR1 expression, transcriptionally activating LCN2 and SOCS3 and aggravating insulin resistance in hepatic, adipose and skeletal muscle cells. The gene discussed is LCN2; the disease is Insulin resistance.