INS and Insulin resistance: Among them, we targeted early growth response 1 (Egr1), lipocalin 2 (Lcn2) and suppressor of cytokine signaling 3 (Socs3), which were relatively high abundant in liver, adipose tissue and skeletal muscle based on human protein atlas and mouse genome informatics database and have been indicated to induce insulin resistance by suppressing the insulin signaling pathway41–45.