G6PD and hyperinsulinemic hypoglycemia, familial, 4: Primaquine is useful for eliminating P. vivax and P. ovale hypnozoites to prevent relapses106 but poses significant risks of hemolytic anemia in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency.402 This necessitates quantitative G6PD testing before administration, a resource often unavailable in endemic areas, further complicating its deployment.