TH2 cells, characterized by GATA3 and IL-4 production, play a limited role in malaria but are essential for robust CD8+ T-cell responses through IL-4-mediated CD4/CD8 cross-talk.288 CD8+ T-cell activity is significantly diminished without CD4+ T-cell support, highlighting their synergy in generating effector cells during immunization with radiation-attenuated sporozoites. The gene discussed is CD8A; the disease is malaria.