Altogether, cross-species comparison of transcriptome, methylome, and histology data revealed a coherent picture, indicating conservation of human sarcoma biology across the sarcoma EPO-GEMM cohort, especially for bona fide fusion-driven sarcomas SS18::SSX, NTRK-Mono, PAX3::FOXO1 and ASPSCR1::TFE3. Here, ASPSCR1 is linked to sarcoma.