Similar to aRMS, tumor induction was dependent on Trp53 inactivation and was more efficient in mice electroporated at P30 rather than at P0 (100% versus 22% penetrance, 33% versus 0% bilateral tumor fraction, 200 versus 269 days of mean latency) (Fig. 1g; Supplementary Fig. 3c, d). Here, TP53 is linked to neoplasm.