Tumors from a previously published conventional GEMM of ASPS, expressing ASPSCR1::TFE3 from the Rosa26 locus, exhibited distinct DNA methylation profiles (Fig. 4a, Supplementary Fig. 4d), possibly reflecting a different cell of origin, given their strictly heterotopic onset in the cranial vault25. This evidence concerns the gene TFE3 and alveolar soft part sarcoma.