Upregulation of embryonal developmental pathways (k-means group 1) was shared between various tumor types, while muscle development and differentiation were specifically upregulated in PAX3::FOXO1 tumors, consistent with mechanistic studies identifying PAX3/7::FOXO1-induced activation of myogenic super enhancers51 (k-means group 7). This evidence concerns the gene FOXO1 and neoplasm.