TIMP3 and breast cancer: Moreover, the mean expression level of 30 signature genes is significantly associated with shorter survival in breast cancer, as demonstrated by data from the TCGA database (log-rank test, p = 0.036) (Fig. 4h–j); (2) conversely, cluster 6 cells over-express IgG genes linked to improved prognosis53, along with tumor-suppressive genes like TIMP3 and LYZ54–56.