To support our findings, we adopted independent approaches: (1) cluster 10 cells exhibit over-expression of genes related to tumor metastasis and epithelial-mesenchymal transition50–52, such as TROP2, TM4SF1, and FABP5. These genes are involved in functions linked to tumor malignancy, including cell division, cell cycle, cell migration, hypoxia, cell proliferation, mechanical stimulus, and degradation of the extracellular matrix. This evidence concerns the gene TM4SF1 and neoplasm.