CASP3 and non-small cell lung carcinoma: Although RG7388 induced a concomitant decrease of mutant p53 expression with an increase of cleaved PARP and cleaved Caspase-3 in a dose-dependent manner (Supplementary Fig. 3A and B), TP53 KD did not cause significant change in the expression of NOXA in TP53mutant NSCLC cells (Supplementary Fig. 3C).