Although RG7388 induced a concomitant decrease of mutant p53 expression with an increase of cleaved PARP and cleaved Caspase-3 in a dose-dependent manner (Supplementary Fig. 3A and B), TP53 KD did not cause significant change in the expression of NOXA in TP53mutant NSCLC cells (Supplementary Fig. 3C). Here, PMAIP1 is linked to non-small cell lung carcinoma.