We further found that CTCF-EZH2 contributes to the repressive chromatin status on the OR51B5 promoter and impaired the entry of RNA polymerase II, subsequently inactivating OR51B5 to activate N-Ras expression and promote the growth and metastasis of esophageal cancer (Fig. 7H). The gene discussed is OR51B5; the disease is esophageal cancer.