OR51B5 and neoplasm of esophagus: We next examined whether closed chromatin status at OR51B5 core promoter would inactivate the expression of OR51B5. By comparing the gene expression profiles between esophageal tumor and normal tissues, RNA-seq data (GEO: GSE194116) showed that 5792 differentially expressed genes were identified, including 2729 up-regulated genes and 3063 down-regulated genes.