We showed that the chromatin status of OR51B5 promoter (chr11:5,505,652–5,507,152) was actually closed (Fig. 1F, middle; Fig. 1G, lanes 5–6) as compared with upstream control site OR51B8P and downstream control site UBQLN3 in ESCC cells (Fig. 1F, left and right), while the OR51B5 promoter remained in an open chromatin status human esophageal epithelial cell Ne-3 (Fig. 1F, cycle; Fig. 1G, lane 4). The gene discussed is UBQLN3; the disease is esophageal squamous cell carcinoma.