Next, we detected the H3K27 trimethylation enrichment in the OR51B5 promoter region by ChIP-qPCR assay, H3K27me3 level at the OR51B5 promoter were significantly elevated in ESCC cells compared to Ne-3 cell (Fig. 2C, cycle and diamond; Fig. 2D, lanes 2–3). Here, ELANE is linked to esophageal squamous cell carcinoma.