Mutations in DAGLα are associated with neurodevelopmental disorders and cerebellar ataxias in humans (Knight et al., 2008; Smith et al., 2017; Bainbridge et al., 2022) and are implicated in one of the most common neurodevelopmental diagnoses, autism spectrum disorder (ASD; Shonesy et al., 2014, 2018; Jenniches et al., 2016; Fyke et al., 2021). Here, DAGLA is linked to cerebellar ataxia.