A recent report in 2022 described nine children with heterozygous de novo truncating mutations in the C-terminal tail of DAGLα (affecting phosphorylation sites, Homer interactions, DAGLα localization, and on-demand production of 2-AG) who exhibit delayed motor and verbal-communication development together with the typical cerebellar symptoms, such as ataxia and nystagmus (Bainbridge et al., 2022). This evidence concerns the gene DAGLA and pathologic nystagmus.