In obesity, adipose tissue is characterized by hypertrophy and hyperplasia of white adipocyte cells, which results in key local and systemic changes such as increased levels of free fatty acids, triglycerides, blood glucose, insulin resistance, as well as altered secretion of growth hormones, inflammatory cytokines, and adipokines [58]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.