Interestingly, we found that knockdown of AhcyL1 and AhcyL2, which potentially elevates S-adenosyl homocysteine hydrolase Ahcy activity (Parkhitko et al., 2016), elevated H3K9me3 levels and strongly inhibited dlg mutant tumor growth (Fig. 3H). The gene discussed is AHCY; the disease is neoplasm.