Consistent with this hypothesis we have identified a distinct neutrophil transcriptional profile in Apoe-/- mice that are highly susceptible to infection with Mtb which is similar to that described in N2 TANs, while the transcriptional profile of neutrophils from Ldlr-/- mice that are more resistant to Mtb is similar to that described in N1 TANs. Here, LDLR is linked to infection.