SRSF6 and viral infectious disease: Importantly, EV-A71 virus infection induced the phosphorylation and cytoplasmic relocalization of SR proteins, which co-localized with vRNA and co-sedimented with components of the translation apparatus, Functional analyses demonstrated that the knockdown of specific SR proteins, including SRSF4, SRSF5, and SRSF6, significantly attenuated viral replication.