This could be due to 24 hours post-infection (hpi) being a relatively late time after infection and to the fact that it has been previously described that SARS-CoV-2 protein N is able to antagonize PKR activation [61], as well as the nsp15 of coronaviruses could have an important function on antagonizing PKR-eIF2α antiviral pathway to ensure an efficient replication [24,25,62]. The gene discussed is EIF2AK2; the disease is infection.