Ogura et al. [29] conducted an experiment with a rat model of endotoxemia and showed that landiolol hydrochloride ameliorated the up-regulation of the HIF-1α-ET-1 system in the kidneys with minimal morphological damage and normalized biomarkers of early renal injury in this rat model of endotoxemia. Here, EDN1 is linked to serum lipopolysaccharide activity.