The same findings were obtained in the hippocampal tissues, where MDA significantly increased by 30.1% in the hippocampus of the rat model of depression group on animals, however, both HSP-NPs and QUR-NPs were able to recover the MDA level to control-like values with a non-significant decrease of 13.9% and 3.7%, respectively. This evidence concerns the gene HSP90B2P and major depressive disorder.