Moreover, Metformin efficiently counteracted p53 and p21 induction by the Mdm2 inhibitor Nutlin‐3 [60] in both U2OS and HCT116 colon cancer cells (Figure S1D), further supporting the notion that Metformin can downregulate p53 via an HPV‐independent mechanism. The gene discussed is TP53; the disease is malignant colon neoplasm.