Investigation into the contribution of CXCL10 in neurological disease has identified elevated levels of CXCL10 to be present in multiple sclerosis, Alzheimer's disease, and cerebral malaria (Xia et al. 2000; Sørensen et al. 2002; Wilson et al. 2011; Zaheer et al. 2013). Here, CXCL10 is linked to early-onset autosomal dominant Alzheimer disease.