NPTX2 and Alzheimer disease: In the AD group, CSF NPTX2 retained a modest correlation with CSF SNAP‐25 (R = 0.59, CI95% = 0.37–0.75, p < 0.001) and a weak correlation with CSF t‐Tau (R = 0.39, CI95% = 0.11–0.61, p < 0.01), CSF p‐Tau181 (R = 0.46, CI95% = 0.2–0.66, p = 0.001), as well as a weak negative correlation with the CSF Aβ1‐42/1‐40 ratio (R = −0.29, CI95% = −0.53 to −0.01, p < 0.05) (Figure S5C).