Furthermore, in discriminating the aDS group from the symptomatic DS groups (pDS and dDS), NPTX2 showed the highest AUC in dDS (AUC = 0.64, CI95% = 0.56–0.72; Figure 3E) followed by pDS (AUC = 0.54, CI95% = 0.39–0.68; Figure 3E) CSF NPTX2 levels in DS individuals were then assessed in relation to intellectual disability (mild, moderate, severe), both in the full cohort and in the three separate subgroups. Here, NPTX2 is linked to Intellectual disability.