As mentioned above, the levels of NPTX2 in AD in this study were significantly lower than controls, which is also the case for other neurodegenerative diseases, such as DLB,26, 27, 29 atypical parkinsonism (PSP, MSA)30 and FTD.26, 27, 28. Here, NPTX2 is linked to supranuclear palsy, progressive, 1.