METTL14 and carcinoma of esophagus: Mechanistically, m6A imbalance promotes oncogenesis by altering tumorsuppressor and oncogene signaling—exemplified by METTL14-driven m6Amodifications accelerating pancreatic cancer metastasis, and viral-induced METTL3overexpression exacerbating esophageal carcinoma progression (45, 46).