These include pleural effusion, obesity, age, blood urea nitrogen, serum creatinine, hematocrit, C-reactive protein (CRP), procalcitonin, as well as scoring systems that incorporate multiple parameters such as the Ranson score, systemic inflammatory response syndrome (SIRS), bedside index of severity in AP (BISAP), and acute physiology and chronic health evaluation (APACHE-II) score.6, 7. This evidence concerns the gene CRP and systemic inflammatory response syndrome.