Pursuing this, we first validated the in vivo interaction of EGFR with CMTM6 using five representative NSCLC cell lines: PC‐9 and HCC827 with EGFR exon 19 deletion (EGFR exon 19del), NCI‐H1975 (EGFR/L858R+T790M), as well as the EGFR wild‐type cell line A549 and NCI‐H1299. This evidence concerns the gene EGFR and non-small cell lung carcinoma.