In this study, the methylation status and expression levels of the genes SFRP2, SFRP4, SFRP5,APC1, and APC2 genes, which are involved in the Wnt pathway, were investigated in samples taken from the proximal and left side colon of patients with left-sided UC who underwent surveillance colonoscopy, and healthy individuals who underwent cancer screening. The gene discussed is SFRP4; the disease is cancer.