CK2α is an essential serine/threoninekinase critical for cellular signaling and implicated in multiplepathologies including cancers and Alzheimer’s disease., It phosphorylates hundreds of substrates,, including activation of Akt, which drives PI3K/Akt pathway dysregulationand tumorigenesis., Notably, CK2α is overexpressedin multiple cancer cell lines, such as the cervical carcinoma HeLacells and the colon cancer HCT116 cells., Besides, CK2α is modified by multiple PTMs, including phosphorylationat Thr344, Thr360, Ser362, and Ser370, as well as O-GlcNAcylationat Ser347 (Figure A,B).,, Here, AKT1 is linked to early-onset autosomal dominant Alzheimer disease.