To metastasize,tumor cells must degrade the extracellular matrix using MMP2 and MMP9 enzymes, allowing them to migrate to newtissues. Both MMP2 and MMP9 expressions were reduced after niclosamide treatment(p < 0.05), which suggests that suppression ofthese enzymes may reduce the metastatic potential of the tumor. The gene discussed is MMP9; the disease is neoplasm.