TP53 and head and neck squamous cell carcinoma: These findings suggest thatniclosamide induces a G1-phase cell cycle arrest, potentially by inhibitingcell cycle progression through mechanisms involving cyclin-dependentkinases (CDKs) or tumor suppressor proteins like p53. The accumulation of cells in the G0/G1 phase, coupled withsubsequent apoptotic death, is often seen in response to unresolvedDNA damage or irreparable stress signals. Han et al. aimed to investigate the therapeutic potential of niclosamidein head and neck squamous cell carcinoma (HNSCC) and to explore itsunderlying molecular mechanisms.