ROS1 and cancer: Aberrant kinase activity stands as a hallmark of cancer, oftenattributed to oncogenic events encompassing gene amplification, activatingmutations, and fusion proteins. A notablecase involves the oncogenic fusion event where the ROS proto-oncogene1 (ROS1) kinase domain fuses with various partners. Across diverse cancer types in both adults and children,ROS1 fusion proteins have been identified as significant drivers ofoncogenesis.