While we included leptin, IL-6, IL-1β, TNF-α, and CRP, we did not assess other cytokines such as MCP-1, IL-18, or markers of microglial activation and phenotype (e.g., CD68 and sTREM2), which may play significant roles in glial reactivity in Alzheimer's disease. Here, TNF is linked to early-onset autosomal dominant Alzheimer disease.