TRIM16 and lung cancer: Subsequently, our mass spectrometry analysis identified TRIM16, a known E3 ubiquitin ligase which was reported to promote the ubiquitination of Vimentin in lung cancer cells, as a potential LncPTEN1-interacting protein (Fig. 7E, Fig. S5A) [33], indicating that LncPTEN1 may suppress lung cancer progression by modulating TRIM16-mediated degradation of Vimentin.