To investigate the role of Slc25a20 in the development of pancreatic cancer, Slc25a20+/- mice were mated with a Kras-driven pancreatic cancer model (KrasG12D/+; Trp53R172H/+; Pdx1-Cre mouse, KPC mouse) 23. The gene discussed is PDX1; the disease is pancreatic neoplasm.