Anti-IFNα/βR mAb treatment eliminated periodontitis-associated arthritis exacerbation, as evidenced by comparable levels of hind paw thickness, bone erosion, synovial inflammation, and cartilage destruction between Ctrl + CAIA and LIP + CAIA groups receiving anti-IFNα/βR mAb (Figure S6A-E). Here, IFNAR2 is linked to periodontitis.