Notably, SPOP exerts its effects through the regulation of key factors such as FAS-associated death structural domain (FADD) and SIRT2 in lung cancer, MyD88 and chromatin assembly factor 1 subunit A (CHAF1A) in DLBLC, DHX9 in choriocarcinoma, EWS-FLI1 in Ewing sarcoma, and signal transducers and transcriptional activators 3 (STAT3) in bladder cancer. Here, STAT3 is linked to Ewing sarcoma.