Mutations in the MATH domain (G75L and G132R) and BTB domain (G192A and K279N) of SPOP in NSCLC impair its ability to degrade SIRT2 and suppress NSCLC cell growth, highlighting a strong correlation between SPOP's degradation of SIRT2 and its role in inhibiting NSCLC cell proliferation 88. Here, SPOP is linked to non-small cell lung carcinoma.