As represented in Table 4 and Figure 7, SPOP plays a crucial role in the degradation of several oncogenic proteins including SENP7, Nogo-B, 3-hydroxy-3-methylglutaryl-CoA synthase 1 (HMGCS1), interferon regulatory factor 2-binding protein 2 (IRF2BP2), and B cell lymphoma-2-associated transcription factor 1 (BCLAF1) in HCC; Gli2, HDAC6, and ILF3 in CRC; Gli2 and T lymphoma invasion and metastasis 1 (TIAM1) in GC; Nanog in pancreatic cancer. This evidence concerns the gene GLI2 and familial pancreatic carcinoma.