Recent studies have uncovered the oncogenic properties of Cdc20, with its overexpression observed in numerous human cancers 158-161, including non-small cell lung cancer (NSCLC) 162, breast cancer 163,164, pancreatic cancer 165, CRC 166, HCC 167, gastric cancer (GC) 168, glioblastoma 169, PCa 170, and bladder, oral, and cervical cancers 171,172. This evidence concerns the gene CDC20 and posterior cortical atrophy.