Further correlation analysis was performed using principal component from each module against key clinical parameters, including metabolic indices (body mass index, fasting glucose level, and history of diabetes), cardiovascular indices (blood pressure, heart rate, hypertension, and pro-BNP level), kidney function indices (BUN, GFR, and CKD), and death outcomes (Figure 1B). The gene discussed is NPPB; the disease is hypertensive disorder.