In contrast, acquired eccDNA is predominantly larger (>100 kb to several megabases) and arises in contexts of genomic instability, such as cancer or chronic inflammation, which arises in pathological conditions, such as cancer or genomic instability, and is often enriched in oncogenes such as EGFR, MYC, and MET, as well as stress-response genes like HSP90 and SOD2, contributing to disease progression and therapeutic resistance 18,47,77-79. The gene discussed is SOD2; the disease is cancer.