In metabolic disorders, such as newly diagnosed type 2 diabetes mellitus (T2DM) patients, a novel circulating eccDNA, SORBS1-circle, is markedly elevated in patients and correlates positively with key indicators of metabolic dysfunction, including HbA1c and homeostatic model assessment for insulin resistance (HOMA-IR) 126. The gene discussed is SORBS1; the disease is type 2 diabetes mellitus.