Recent studies indicate that running exercise decreases Iba-1+/iNOS+ microglia or Iba-1+/CD68+ microglia and alleviates neuroinflammation in the hippocampus of murine models of HFD-induced type 2 diabetes and chronic unpredictable stress-induced depression 41, 67. Here, AIF1 is linked to type 2 diabetes mellitus.