Notably, organ-specific stromal responses occur—pulmonary ECs downregulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) under VEGF stimulation to promote PMN formation, whereas hepatic sinusoidal ECs increase fibronectin expression via TGF-β1 to drive tumor progression 15, 16. The gene discussed is TNFSF10; the disease is neoplasm.