For example, colorectal cancer-derived EVs (e.g., ADAM17 and miR-27b-3p) synergistically promote vascular leakage by interfering with the membrane localization of VE-cadherin and regulating the expression of tight junction proteins (ZO-1/occludin/Claudin5) via the KLF2/KLF4-VEGFR2 axis 92-94. Here, ADAM17 is linked to colorectal cancer.