Consistence with previous observation that SUMO modification can mediate the redistribution of target proteins, and recent high-resolution imaging studies show that the SARS-CoV-2 Spike protein localizes to the nuclear membrane during late stages of infection 36, our findings suggest that this re-localization may be driven by SUMO modification and linked to the perinuclear puncta of SUMO2. This evidence concerns the gene SUMO2 and infection.