VCAN and Granuloma: Selective genes upregulated in granuloma were linked to various biological processes including immune response (IL10RA, CXCL9, CCR5, TNFAIP3, MARCO, MRC1, and CD163), surface receptors (IL7Rα, IL4R, IL18R1, IL10RA, CCR5, CXCR4, IL2RA, and TLR4), and ECM deposition (COL1A1, COL3A1, COL5A1, VCAN, POSTN, and FN1) (Figure 2C).