In DE lesions, it is possible that they may have HDAC3 inactivation which has been reported in eutopic endometrium from women with either endometriosis (Kim et al., 2019) or adenomyosis (Mao et al., 2023) and may lead to ERα mRNA instability (Oie et al., 2013), resulting in depressed ERα. Here, ESR1 is linked to adenomyosis.