Equally inexplicably, adenomyosis (AD) and certain subtypes of endometriosis, such as deep endometriosis (DE), do not respond to hormonal treatment as well as ovarian endometrioma (OE) (Stratopoulou et al., 2021; Vannuccini et al., 2022), and aromatase inhibitors show no superior efficacy (Csirzo et al., 2024). The gene discussed is CYP19A1; the disease is Alzheimer disease.