Our results of activated estrogen signaling as well as reduced ERα expression in OE and AD lesions are consistent with overwhelming data showing the same (Yamamoto et al., 1993; Brandenberger et al., 1999; Fujimoto et al., 1999; Attar et al., 2009; Mehasseb et al., 2011; Heublein et al., 2012; Samartzis et al., 2012). Here, ESR1 is linked to Alzheimer disease.