However, the previous CA patients’ cells showed decreased LPS-induced secretion of IFN-α (p ≤ 0.001), IFN-γ (p ≤ 0.001) and IL-12 (p ≤ 0.001) and decreased R848-induced secretion of IFN-α (p ≤ 0.001), while the secretion of IL-1β was increased after stimulation with R848 (p ≤ 0.001). Here, IL1B is linked to cancer.