Additionally, BPH scRNA-seq datasets analysis demonstrated that epidermal growth factor receptor (EGFR) expression was significantly higher in Fin-P BE cells than in Fin-N BE cells (Fig. S11C), and EGFR-positive BE cells exhibited a significantly higher PCNA expression level than EGFR-negative BE cells in Fin-P tissues (Fig. 1I). Here, PCNA is linked to Barrett esophagus.