Considering the well-documented pivotal role of EGFR in driving cell proliferation across diverse cancer types,5 we infer that the activation of EGFR on BE cells, stimulated by specific factors such as transforming growth factor-beta 1 (TGF-β1) secreted by LE cells, may potentiate BE cell proliferation. This evidence concerns the gene TGFB1 and Barrett esophagus.