GFI1 and acute myeloid leukemia: In 2016, Jiang et al43 demonstrated that in acute myeloid leukemia, miR-22 was suppressed through epigenetic repression involving TET1, along with SIN3 transcription regulator family member A (SIN3A), EZH2, and growth factor independent 1 (GFI1), as well as DNA copy-number loss.