Overexpression of TET1 transformed normal B cells into B-cell acute lymphoblastic leukemia cells by promoting the transcription of cluster of differentiation 72 (CD72) and joining chain of multimeric IgA and IgM (JCHAIN) through signal transducer and activator of transcription 5B (STAT5B) interactions. The gene discussed is TET1; the disease is B-cell acute lymphoblastic leukemia.