TET1 and obesity due to melanocortin 4 receptor deficiency: Additionally, TET3 is involved in metabolic regulation, including adipocyte differentiation and glucose homeostasis, indicating its potential role in metabolic diseases such as obesity and diabetes.20, 21, 22 The functions of TET1, TET2, and TET3 are often interconnected, with complementary or compensatory roles in various biological contexts.