In conclusion, although the effect of KLHL17P234L requires further in-depth study, for example, more molecular experiments are needed to identify the specific targets or interacting genes of KLHL17 in neurodevelopmental disorders, as well as more behavioral experiments across different time points to undertake more detailed analysis of the pathological effect of the P234L mutation on neuronal development in vivo, our findings furnish novel research cues for understanding the molecular pathogenesis and mechanism of KLHL17-related neurodevelopmental disorders. The gene discussed is KLHL17; the disease is neurodevelopmental disorder.