The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway emerges as a pivotal signal pathway implicated in cell proliferation, migration, differentiation, and metabolism; it has been considered a key driver of neurogenesis and its dysregulation has been implicated in the pathogenesis of various neurodevelopmental disorders, including autism spectrum disorder and intellectual disability.5 Here, AKT1 is linked to autism spectrum disorder.