Kelch-like family member 17 (KLHL17) is predominantly expressed in the brain and plays a crucial role in neuronal development and function, deletions and/or mutations in KLHL17 have been linked to neurodevelopmental disorders in humans, e.g., intellectual disability, autism spectrum disorder, and infantile spasms, but the etiology and pathogenesis remain largely enigmatic.1 Here, KLHL17 is linked to neurodevelopmental disorder.