AKT1 and Intellectual disability: The phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) pathway emerges as a pivotal signal pathway implicated in cell proliferation, migration, differentiation, and metabolism; it has been considered a key driver of neurogenesis and its dysregulation has been implicated in the pathogenesis of various neurodevelopmental disorders, including autism spectrum disorder and intellectual disability.5