,3 Previously, we identified a novel de novo variant in KLHL17 (c.701C > T; p. P234L) in a cohort of 225 Chinese children with developmental delay/intellectual disability based on whole-exome sequencing (1/225), the mutation located in the BACK domain, a very high conversed region (Fig. S1B), and the affected boy presented with developmental delay, intellectual disability, hypotonia, and abnormal brainstem auditory evoked potential signal.4 Here, KLHL17 is linked to Global developmental delay.