Although venous thrombosis has traditionally been viewed as coagulation-dominated, studies reveal that platelets play a critical role through procoagulant activation: platelet factor 4 (PF4) promotes deep vein thrombosis by modulating NET formation (63), while cyclophilin D and transmembrane protein 16F deficiencies in murine models demonstrate the regulatory role of platelet activation pathways in thrombosis susceptibility (64). This evidence concerns the gene PF4 and deep vein thrombosis.