Notably, NLRP3 cooperates with Bruton's tyrosine kinase (BTK) to amplify platelet aggregation and thrombosis, particularly in diseases like sickle cell anemia (SCD), where HMGB1/TLR4-NLRP3/BTK crosstalk exacerbates thrombosis (107–109). The gene discussed is NLRP3; the disease is sickle cell disease.