NLRP3 and deep vein thrombosis: TGF-β cooperates with IL-10 to suppress NLRP3 activation, demonstrating context-dependent functions, facilitating transient extracellular matrix repair in acute DVT resolution (156, 157), yet promoting SMAD3-dependent fibrosis through α-SMA + myofibroblast activation in chronic post-thrombotic syndrome, ultimately resulting in venous wall stiffening and valvular dysfunction (158, 159).