Notably, NLRP3 cooperates with Bruton's tyrosine kinase (BTK) to amplify platelet aggregation and thrombosis, particularly in diseases like sickle cell anemia (SCD), where HMGB1/TLR4-NLRP3/BTK crosstalk exacerbates thrombosis (107–109). This evidence concerns the gene BTK and Schnyder corneal dystrophy.