Moreover, Xu et al. demonstrated that L-sorbitol interferes with glycolysis through KHK-mediated phosphorylation, leading to increased oxidative stress and mitochondrial damage in tumor cells, which weakens KHK-A-related antioxidant genes and induces tumor cell apoptosis, suggesting that KHK may have a tumor-suppressive role under specific metabolic conditions 159. Here, KHK is linked to neoplasm.