Liu et al. found that the absence of ALDOB, by activating the PI3K-AKT signaling and promoting lipogenesis, drives the progression of HCC, whereas its interaction with the insulin receptor regulates glycolipid metabolism and the restoration of ALDOB expression significantly inhibits tumor formation, demonstrating its potential as an anticancer agent 198. The gene discussed is AKT1; the disease is hepatocellular carcinoma.