STAT3 and neoplasm: In addition to this, it was found that alterations in intestinal bacterial profiles (B. fragilis, Butyrivibrio fibrisolvens and Firmicutes Streptococcus digestans increase in relative abundance) in the deficiency of vitamin D receptor also hyperfunction JAK and enhance STAT3 expression in the organ, leading to hyperfunction of JAK/STAT3 signaling, which promotes tumor development56.