The above studies suggest that intestinal flora can mediate the involvement of necroptosis-related genes including STAT3, MYC and SQSTM1 in colorectal tumor development through the Wnt/β-catenin signaling pathway, IL-6/JAK1/STAT3 signaling pathway and mTORC1-c-MYC axis respectively. Here, STAT3 is linked to colorectal neoplasm.