TP53 and nonpapillary renal cell carcinoma: KEGG enrichment analysis performed on the filtered DEGs revealed that these genes were enriched in critical pathways associated with lipid metabolism, atherosclerosis, NOD-like receptor signaling, transcriptional dysregulation, p53 signaling, PI3K-AKT signaling, and PPAR signaling, among others, indicating their relevance in the progression of ccRCC (Figure 7E).