TNFRSF1B (also known as TNFR2), part of the TNF receptor superfamily TRAF (TNF receptor-associated factor) interaction subgroup, co-stimulates CD8+ T cells and sensitizes tumor cells to TNFR1-mediated cytotoxicity 35, and is instrumental for CD8+ T cell activation and cytotoxicity during early immune responses. Here, CD8A is linked to neoplasm.