In recent years, molecular targeted therapy has significantly improved in non-small cell lung cancer, offering enhanced alternatives for clinical diagnosis and treatment, particularly for advanced lung adenocarcinoma and other lung cancer variants with adenocarcinoma components, EGFR tyrosine kinase inhibitors (EGFR-TKIs) have emerged as the primary pharmacological agents for the management of intermediate and advanced non-small cell lung cancer, these novel targeted medicines not only markedly enhanced clinical results but also prolonged patient survival (9, 11, 12). This evidence concerns the gene EGFR and lung adenocarcinoma.