The prognosis after ESD treatment was taken as the dependent variable (0 = good prognosis, 1 = poor prognosis) and the factors (tumor size, lymph node metastasis, preoperative serum CEA level, Bacteroides abundance and Enterococcus abundance) with p < 0.05 in univariate analysis were taken as the covariates for further multivariate Logistic regression analysis. Here, CEACAM5 is linked to metastatic malignant neoplasm in the lymph nodes.