NFKB1 and infarction: Taking the TLR2/TLR4/NF-κB pathway as the entry point, we found that the mRNA and protein expression of TLR2, TLR4, and NF-κB were progressively upregulated with the prolongation of infarction time (Figure 6), and a significant difference was observed in the 12 h compared with the Sham group (⁣∗∗p < 0.01).