Significantly enriched signaling pathways were identified primarily in the context of rheumatoid arthritis, the role of AGE-RAGE signaling pathway in diabetic complications, TNF signaling pathway, focal adhesion, osteoclast differentiation, cytokine–cytokine receptor interaction, extracellular matrix (ECM) receptor interaction, TLR signaling pathway, and fluid shear stress and atherosclerosis signaling pathway (Figure 2d). This evidence concerns the gene RENBP and rheumatoid arthritis.