The four folds upregulation of ubiquitin C-terminal hydrolase L1 (UCHL1) and PPP2R2D, a subunit of protein phosphatase 2A, suggests altered signalling pathways and protein turnover in human brain (Bishop et al., 2016), which are associated with neurodegenerative diseases. The gene discussed is PPP2R2D; the disease is neurodegenerative disease.