(Samson et al., 2008) Aggregation of certain protein and inflammation of developing genes such as reticulon 3 (RTN3) (Grumati et al., 2017) and C1q and tumour necrosis factor-related protein 4 (C1QTNF4) (Vester et al., 2021) can act as central to the development and prognosis of AD. This evidence concerns the gene C1QTNF4 and Alzheimer disease.