In molecular function, kinase binding (adjusted p-value = 0.03205, combined score = 89.70) and protein phosphatase regulator activity (adjusted p-value = 0.03324, combined score = 278.70) highlighted the disruption in protein phosphorylation as a tau-related AD precursor (Iqbal et al., 2010). The gene discussed is MAPT; the disease is Alzheimer disease.